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Individual differences in schizophrenia
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Rolls, Edmund T., Lu, Wenlian, Wan, Lin, Yan, Hao, Wang, Chuanyue, Yang, Fude, Tan, Yunlong, Li, Lingjiang, Yu, Hao, Liddle, Peter F., Palaniyappan, Lena, Zhang, Dai, Yue, Weihua and Feng, Jianfeng (2017) Individual differences in schizophrenia. BJPsych Open, 3 (6). pp. 265-273. doi:10.1192/bjpo.bp.117.005058 ISSN 2056-4724.
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Official URL: https://doi.org/10.1192/bjpo.bp.117.005058
Abstract
Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia.To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how first-episode patients (FEP) may differ from multiple episode patients (MEP).These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks.The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups.The negative symptoms are a major source of individual differences, and there are potential implications for treatment.L.P. received speaker fees from Otsuka Canada and educational grant from Janssen Canada in 2017.© The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Schizophrenia -- Diagnosis, Schizophrenia -- Treatment | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | BJPsych Open | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Royal College of Psychiatrists | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 2056-4724 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Official Date: | 8 November 2017 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Volume: | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number: | 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 265-273 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1192/bjpo.bp.117.005058 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 25 April 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 25 April 2018 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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