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Cellular and molecular action of the putative GABA-mimetic, gabapentin
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UNSPECIFIED (2003) Cellular and molecular action of the putative GABA-mimetic, gabapentin. CELLULAR AND MOLECULAR LIFE SCIENCES, 60 (4). pp. 742-750. ISSN 1420-682X
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Official URL: http://dx.doi.org/10.1007/s00018-003-2108-x
Abstract
Gabapentin was originally designed as an anticonvulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier. In the present review we show that although gabapentin is not a GABA mimetic, it has great utility as an add-on therapy for epilepsy and as a first-line treatment for neuropathic pain. We summarise the studies that have been performed which demonstrate that gabapentin appears to interact with a novel binding site expressed at high density within the central nervous system (CNS), namely the alpha2delta voltage-dependent calcium channel subunit. The review continues by examining the effects of gabapentin on calcium channel function and neurotransmitter release before, in the latter part of the review, summarising the more recently discovered actions of gabapentin in relation to intracellular signalling.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Journal or Publication Title: | CELLULAR AND MOLECULAR LIFE SCIENCES |
| Publisher: | BIRKHAUSER VERLAG AG |
| ISSN: | 1420-682X |
| Date: | April 2003 |
| Volume: | 60 |
| Number: | 4 |
| Number of Pages: | 9 |
| Page Range: | pp. 742-750 |
| Identification Number: | 10.1007/s00018-003-2108-x |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/9701 |
Data sourced from Thomson Reuters' Web of Knowledge
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