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Analysing the impact of iron dysmetabolism on regional metal ion distribution in the brain
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Norman, D. G., Finnegan, M. E. and Collingwood, J. F. (2011) Analysing the impact of iron dysmetabolism on regional metal ion distribution in the brain. In: Undergraduate Research Scholarship Scheme 2011, University of Warwick, Nov 2011 (Unpublished)
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Abstract
An Iron Overload and an H-Ferritin Deficient Mouse Model were used to examine the impact of disrupted iron metabolism on the brain. Brain sections were imaged and compared using Synchrotron μXRF spectroscopy. Quantitative measurement of the relative metal ion concentrations for iron, copper and zinc were made across selected regions of interest in the brain. It was generally found that metal ion concentrations of iron and zinc decreased in specific regions in the Iron Overload condition compared with the control, with copper increasing in only one region. Few regions differed in metal ion concentration between the H-Ferritin Deficient Model and the control. The three conditions exhibited similar / identical results for metal ion concentrations in many brain regions, indicating the validity of the method used for comparison between samples. It is clear that there exists a complex relationship between these trace metals
Item Type: | Conference Item (Poster) | ||||
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Alternative Title: | |||||
Subjects: | Q Science > QP Physiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Psychology |
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Official Date: | 1 September 2011 | ||||
Dates: |
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Status: | Not Peer Reviewed | ||||
Publication Status: | Unpublished | ||||
Date of first compliant deposit: | 8 January 2018 | ||||
Conference Paper Type: | Poster | ||||
Title of Event: | Undergraduate Research Scholarship Scheme 2011 | ||||
Type of Event: | Other | ||||
Location of Event: | University of Warwick | ||||
Date(s) of Event: | Nov 2011 |
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