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Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda
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Prada, Joaquín M., Touloupou, Panayiota, Adriko, Moses, Tukahebwa, Edridah M., Lamberton, Poppy H. L. and Hollingsworth, T. Déirdre (2018) Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda. Parasites & Vectors, 11 (21). doi:10.1186/s13071-017-2580-z ISSN 1756-3305.
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Official URL: http://dx.doi.org/10.1186/s13071-017-2580-z
Abstract
BACKGROUND:
Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring.
RESULTS:
We created a model of schistosome infections to better understand and quantify the relationship between these two egg- and adult worm antigen-based diagnostics. We focused particularly on the interpretation of "trace" results after CCA testing. Our analyses suggest that CCA is generally a better predictor of prevalence, particularly after treatment, and that trace CCA results are typically associated with truly infected individuals.
CONCLUSIONS:
Even though prevalence rises to pre-treatment levels only six months after MDAs, our model suggests that the average intensity of infection is much lower, and is probably in part due to a small burden of surviving juveniles from when the treatment occurred. This work helps to better understand CCA diagnostics and the interpretation of post-treatment prevalence estimations.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Science > Statistics |
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Library of Congress Subject Headings (LCSH): | Schistosomiasis -- Prevention -- Uganda, Vector-pathogen relationships | ||||||||||||||||||
Journal or Publication Title: | Parasites & Vectors | ||||||||||||||||||
Publisher: | BioMed Central Ltd. | ||||||||||||||||||
ISSN: | 1756-3305 | ||||||||||||||||||
Official Date: | 8 January 2018 | ||||||||||||||||||
Dates: |
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Volume: | 11 | ||||||||||||||||||
Number: | 21 | ||||||||||||||||||
Number of Pages: | 8 | ||||||||||||||||||
DOI: | 10.1186/s13071-017-2580-z | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 25 September 2018 | ||||||||||||||||||
Date of first compliant Open Access: | 25 September 2018 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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