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Time-series transcriptomics reveals that AGAMOUS-LIKE22 affects primary metabolism and developmental processes in drought-stressed Arabidopsis
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(2016) Time-series transcriptomics reveals that AGAMOUS-LIKE22 affects primary metabolism and developmental processes in drought-stressed Arabidopsis. The Plant Cell, 28 (2). pp. 345-366. doi:10.1105/tpc.15.00910 ISSN 1040-4651.
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WRAP-time-series-transcriptomics-reveals-that-AGAMOUS-LIKE22-Ott-2016.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2394Kb) | Preview |
Official URL: http://dx.doi.org/10.1105/tpc.15.00910
Abstract
In Arabidopsis thaliana, changes in metabolism and gene expression drive increased drought tolerance and initiate diverse drought avoidance and escape responses. To address regulatory processes that link these responses, we set out to identify genes that govern early responses to drought. To do this, a high-resolution time series transcriptomics data set was produced, coupled with detailed physiological and metabolic analyses of plants subjected to a slow transition from well-watered to drought conditions. A total of 1815 drought-responsive differentially expressed genes were identified. The early changes in gene expression coincided with a drop in carbon assimilation, and only in the late stages with an increase in foliar abscisic acid content. To identify gene regulatory networks (GRNs) mediating the transition between the early and late stages of drought, we used Bayesian network modeling of differentially expressed transcription factor (TF) genes. This approach identified AGAMOUS-LIKE22 (AGL22), as key hub gene in a TF GRN. It has previously been shown that AGL22 is involved in the transition from vegetative state to flowering but here we show that AGL22 expression influences steady state photosynthetic rates and lifetime water use. This suggests that AGL22 uniquely regulates a transcriptional network during drought stress, linking changes in primary metabolism and the initiation of stress responses.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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Subjects: | Q Science > QK Botany | ||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Arabidopsis -- Metabolism, Arabidopsis -- Effect of drought on | ||||||||||||||||||||||||||||||
Journal or Publication Title: | The Plant Cell | ||||||||||||||||||||||||||||||
Publisher: | American Society of Plant Biologists | ||||||||||||||||||||||||||||||
ISSN: | 1040-4651 | ||||||||||||||||||||||||||||||
Official Date: | 11 March 2016 | ||||||||||||||||||||||||||||||
Dates: |
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Volume: | 28 | ||||||||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||||||||
Page Range: | pp. 345-366 | ||||||||||||||||||||||||||||||
DOI: | 10.1105/tpc.15.00910 | ||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||
Date of first compliant deposit: | 18 January 2018 | ||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 18 January 2018 | ||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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