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Modeling and simulation approaches for cardiovascular function and their role in safety assessment
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Collins, Teresa, Bergenholm, Linnéa, Abdulla, Tariq, Yates, J. W. T., Evans, Neil D., Chappell, M. J. (Michael J.) and Mettetal, J. T. (2015) Modeling and simulation approaches for cardiovascular function and their role in safety assessment. CPT : Pharmacometrics & Systems Pharmacology, 4 (3). pp. 175-188. doi:10.1002/psp4.18 ISSN 2163-8306.
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Official URL: http://doi.org/10.1002/psp4.18
Abstract
Systems pharmacology modeling and pharmacokinetic-pharmacodynamic (PK/PD) analysis of drug-induced effects on cardiovascular (CV) function plays a crucial role in understanding the safety risk of new drugs. The aim of this review is to outline the current modeling and simulation (M&S) approaches to describe and translate drug-induced CV effects, with an emphasis on how this impacts drug safety assessment. Current limitations are highlighted and recommendations are made for future effort in this vital area of drug research.
Item Type: | Journal Article | ||||||||||||
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Subjects: | R Medicine > RM Therapeutics. Pharmacology | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||||
Library of Congress Subject Headings (LCSH): | Cardiovascular pharmacology, Pharmacokinetics -- Mathematical models, Drugs -- Physiological effect -- Mathematical models | ||||||||||||
Journal or Publication Title: | CPT : Pharmacometrics & Systems Pharmacology | ||||||||||||
Publisher: | John Wiley & Sons, Inc. | ||||||||||||
ISSN: | 2163-8306 | ||||||||||||
Official Date: | 11 March 2015 | ||||||||||||
Dates: |
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Volume: | 4 | ||||||||||||
Number: | 3 | ||||||||||||
Page Range: | pp. 175-188 | ||||||||||||
DOI: | 10.1002/psp4.18 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
Date of first compliant deposit: | 19 January 2018 | ||||||||||||
Date of first compliant Open Access: | 19 January 2018 | ||||||||||||
RIOXX Funder/Project Grant: |
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