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Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey
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UNSPECIFIED (2003) Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey. EPIDEMIOLOGY AND INFECTION, 130 (2). pp. 285-291. doi:10.1017/S0950268802008051
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Official URL: http://dx.doi.org/10.1017/S0950268802008051
Abstract
A method for the analysis of age-stratified antibody prevalence surveys is applied to a previously reported survey of antibody to rubella virus using oral fluid samples in which the sensitivity of the assay used was shown to be compromised. The age-specific distribution of the quantitative results of antibody tests using oral fluids is modelled as a mixture of strong positive, weak positive and negative components. This yields maximum likelihood estimates of the prevalence at each age and demonstrates that, when used in conjunction with mixture modelling techniques, the results of antibody prevalence studies using oral fluids accurately reflect those obtained using sera.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine Q Science > QR Microbiology > QR355 Virology |
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| Journal or Publication Title: | EPIDEMIOLOGY AND INFECTION | ||||
| Publisher: | CAMBRIDGE UNIV PRESS | ||||
| ISSN: | 0950-2688 | ||||
| Official Date: | April 2003 | ||||
| Dates: |
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| Volume: | 130 | ||||
| Number: | 2 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 285-291 | ||||
| DOI: | 10.1017/S0950268802008051 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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