The Library
Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus
Tools
Tools
Tools
Hughes, Victoria, Richardson, Magnus J. E. and Wall, Mark J. (2018) Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus. British Journal of Pharmacology, 175 (9). pp. 1471-1485. doi:10.1111/bph.14152 ISSN 1476-5381.
|
PDF
WRAP-acute-ethanol-exposure-bidirectional-Wall-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1378Kb) | Preview |
|
![[img]](https://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP-acute-ethanol-bidirectional-adenosine-rat-hippocampus-Wall-2018-a.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (1414Kb) |
Official URL: http://dx.doi.org/10.1111/bph.14152
Abstract
Background and purpose
Ethanol is a widely used recreational drug with complex effects on physiological and pathological brain function. In epileptic patients the use of ethanol can modify seizure initiation and subsequent seizure activity with reports of ethanol being both pro and anti-convulsant. One proposed target of ethanol's actions is the neuromodulator adenosine, which is released during epileptic seizures to feedback and inhibit the occurrence of subsequent seizures. Here we have investigated the actions of acute ethanol exposure on adenosine signalling in rat hippocampus.
Experimental approach
We have combined electrophysiology with direct measurements of extracellular adenosine using microelectrode biosensors in rat hippocampal slices.
Key results
We found that ethanol has bi-directional actions on adenosine signalling: depressant concentrations of ethanol (50 mM) can increase the basal extracellular concentration of adenosine, leading to the inhibition of synaptic transmission, but it can also inhibit activity-dependent adenosine release during seizures. The reduction in activity-dependent adenosine release is in part produced by effects on NMDA receptors although other mechanisms also appear to be involved. Low concentrations of ethanol (10-15 mM) can enhance pathological network activity by selectively blocking activity-dependent adenosine release.
Conclusions and implications
The complex dose-dependent actions of ethanol on adenosine signalling could in part explain the mixture of pro-convulsant and anticonvulsant actions of ethanol that have previously both been reported.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Adenosine, Hippocampus (Brain) | ||||||||
| Journal or Publication Title: | British Journal of Pharmacology | ||||||||
| Publisher: | John Wiley & Sons Ltd. | ||||||||
| ISSN: | 1476-5381 | ||||||||
| Official Date: | May 2018 | ||||||||
| Dates: |
|
||||||||
| Volume: | 175 | ||||||||
| Number: | 9 | ||||||||
| Page Range: | pp. 1471-1485 | ||||||||
| DOI: | 10.1111/bph.14152 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 25 January 2018 | ||||||||
| Date of first compliant Open Access: | 26 April 2018 | ||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
