The Library
Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia
Tools
Tools
Tools
Morter, Richard, Adetifa, Ifedayo, Antonio, Martin, Touray, Fatima, de Jong, Bouke C., Gower, Charlotte M. and Gehre, Florian (2018) Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia. BMC Research Notes, 11 (1). 31. doi:10.1186/s13104-018-3134-y
Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.1186/s13104-018-3134-y
Abstract
Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. Given a recently reported case, we sought to establish whether paragonimiasis should be considered as an important differential diagnosis for human TB in The Gambia, West Africa. We developed a novel PCR-based diagnostic test for Paragonimus species known to be found in West Africa, which we used to examine archived TB negative sputum samples from a cross-sectional study of volunteers with tuberculosis-like symptoms from communities in the Western coastal region of The Gambia. Based on a "zero patient" design for detection of rare diseases, 300 anonymised AFB smear negative sputum samples, randomly selected from 25 villages, were screened for active paragonimiasis by molecular detection of Paragonimus spp. DNA. No parasite DNA was found in any of the sputa of our patient group. Despite the recent case report, we found no evidence of active paragonimiasis infection masking as TB in the Western region of The Gambia.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Journal or Publication Title: | BMC Research Notes | ||||||
| Publisher: | BioMed Central Ltd. | ||||||
| ISSN: | 1756-0500 | ||||||
| Official Date: | 15 January 2018 | ||||||
| Dates: |
|
||||||
| Volume: | 11 | ||||||
| Number: | 1 | ||||||
| Article Number: | 31 | ||||||
| DOI: | 10.1186/s13104-018-3134-y | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
