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Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia

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Morter, Richard, Adetifa, Ifedayo, Antonio, Martin, Touray, Fatima, de Jong, Bouke C., Gower, Charlotte M. and Gehre, Florian (2018) Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia. BMC Research Notes, 11 (1). 31. doi:10.1186/s13104-018-3134-y

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Official URL: http://dx.doi.org/10.1186/s13104-018-3134-y

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Abstract

Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. Given a recently reported case, we sought to establish whether paragonimiasis should be considered as an important differential diagnosis for human TB in The Gambia, West Africa. We developed a novel PCR-based diagnostic test for Paragonimus species known to be found in West Africa, which we used to examine archived TB negative sputum samples from a cross-sectional study of volunteers with tuberculosis-like symptoms from communities in the Western coastal region of The Gambia. Based on a "zero patient" design for detection of rare diseases, 300 anonymised AFB smear negative sputum samples, randomly selected from 25 villages, were screened for active paragonimiasis by molecular detection of Paragonimus spp. DNA. No parasite DNA was found in any of the sputa of our patient group. Despite the recent case report, we found no evidence of active paragonimiasis infection masking as TB in the Western region of The Gambia.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Journal or Publication Title: BMC Research Notes
Publisher: BioMed Central Ltd.
ISSN: 1756-0500
Official Date: 15 January 2018
Dates:
DateEvent
15 January 2018Published
6 January 2018Accepted
Volume: 11
Number: 1
Article Number: 31
DOI: 10.1186/s13104-018-3134-y
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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