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Triggerable multivalent glyconanoparticles for probing carbohydrate–carbohydrate interactions
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Won, Sangho, Hindmarsh, Steven A. and Gibson, Matthew I. (2018) Triggerable multivalent glyconanoparticles for probing carbohydrate–carbohydrate interactions. ACS Macro Letters, 7 . pp. 178-183. doi:10.1021/acsmacrolett.7b00891
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WRAP-Triggerable-multivalent-glyconanoparticles-Won-2018.pdf - Accepted Version - Requires a PDF viewer. Download (2130Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acsmacrolett.7b00891
Abstract
Carbohydrate–carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate–protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer “gate” enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate–carbohydrate interactions are investigated using this tool.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Physics Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Carbohydrates, Nanostructures, Lactose, Enzymes | |||||||||||||||
| Journal or Publication Title: | ACS Macro Letters | |||||||||||||||
| Publisher: | American Chemical Society | |||||||||||||||
| ISSN: | 2161-1653 | |||||||||||||||
| Official Date: | 18 January 2018 | |||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 30 January 2018 | |||||||||||||||
| Volume: | 7 | |||||||||||||||
| Number of Pages: | 6 | |||||||||||||||
| Page Range: | pp. 178-183 | |||||||||||||||
| DOI: | 10.1021/acsmacrolett.7b00891 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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