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Triggerable multivalent glyconanoparticles for probing carbohydrate–carbohydrate interactions

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Won, Sangho, Hindmarsh, Steven A. and Gibson, Matthew I. (2018) Triggerable multivalent glyconanoparticles for probing carbohydrate–carbohydrate interactions. ACS Macro Letters, 7 . pp. 178-183. doi:10.1021/acsmacrolett.7b00891

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Official URL: http://dx.doi.org/10.1021/acsmacrolett.7b00891

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Abstract

Carbohydrate–carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate–protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer “gate” enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate–carbohydrate interactions are investigated using this tool.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Faculty of Science > Physics
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Carbohydrates, Nanostructures, Lactose, Enzymes
Journal or Publication Title: ACS Macro Letters
Publisher: American Chemical Society
ISSN: 2161-1653
Official Date: 18 January 2018
Dates:
DateEvent
18 January 2018Published
16 January 2018Accepted
Volume: 7
Number of Pages: 6
Page Range: pp. 178-183
DOI: 10.1021/acsmacrolett.7b00891
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
CRYOMAT 638661H2020 European Research Councilhttp://dx.doi.org/10.13039/100010663
UNSPECIFIEDEuropean Regional Development Fundhttp://dx.doi.org/10.13039/501100008530
UNSPECIFIEDAdvantage West Midlands (AWM)UNSPECIFIED

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