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Biophotonics of native silk fibrils
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Shimanovich, U., Pinotsi, D., Shimanovich, K., Yu, N., Bolisetty, S., Adamcik, J., Mezzenga, R., Charmet, Jérôme, Vollrath, F., Gazit, E., Dobson, C. M., Kaminski Schierle, G., Holland, C., Kaminski, C. F. and Knowles, T. P. J. (2018) Biophotonics of native silk fibrils. Macromolecular Bioscience, 18 (4). 1700295. doi:10.1002/mabi.201700295 ISSN 1616-5195 .
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Official URL: https://doi.org/10.1002/mabi.201700295
Abstract
Native silk fibroin (NSF) is a unique biomaterial with extraordinary mechanical and biochemical properties. These key characteristics are directly associated with the physical transformation of unstructured,
soluble NSF, into highly organised nano- and microscale fibrils rich in Beta-sheet content. Here, we show that this NSF fibrillation process is accompanied by the development of intrinsic fluorescence in the visible range, upon near-UV excitation, a phenomenon that has not been investigated in detail to date. We probe the optical and fluorescence characteristics of NSF fibrils and explore a route for potential applications in the field of self-assembled optically active biomaterials and systems. In particular, we demonstrate that NSF can be structured into auto-fluorescent microcapsules with a controllable level of beta-sheet content and thus, with controlable fluorescence properties. We show, furthermore, a facile and efficient fabrication route that permits arbitrary patterns of NSF microcapsules to be deposited on substrates under ambient conditions. The resulting fluorescent NSF patterns display a high level of photostability. These results demonstrate the potential of using native silk as a new class of biocompatible photonic material.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | |||||||||||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Biomedical materials, Microcapsules (Biology) | |||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Macromolecular Bioscience | |||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | |||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1616-5195 | |||||||||||||||||||||||||||||||||||||||||||||
| Official Date: | April 2018 | |||||||||||||||||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 18 | |||||||||||||||||||||||||||||||||||||||||||||
| Number: | 4 | |||||||||||||||||||||||||||||||||||||||||||||
| Article Number: | 1700295 | |||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1002/mabi.201700295 | |||||||||||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 31 January 2018 | |||||||||||||||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 18 June 2018 | |||||||||||||||||||||||||||||||||||||||||||||
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