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What’s in a name? Species-wide whole-genome sequencing resolves invasive and noninvasive lineages of salmonella enterica serotype Paratyphi B
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(2016) What’s in a name? Species-wide whole-genome sequencing resolves invasive and noninvasive lineages of salmonella enterica serotype Paratyphi B. mBio, 7 (4). e00527-16. doi:10.1128/mBio.00527-16 ISSN 2150-7511.
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Official URL: http://dx.doi.org/10.1128/mBio.00527-16
Abstract
For 100 years, it has been obvious that Salmonella enterica strains sharing the serotype with the formula 1,4,[5],12:b:1,2 - now known as Paratyphi B - can cause diseases ranging from serious systemic infections to self-limiting gastroenteritis. Despite considerable predicted diversity between strains carrying the common Paratyphi B serotype, there remain few methods that subdivide the group into groups that are congruent with their disease phenotypes. Paratyphi B therefore represents one of the canonical examples in Salmonella where serotyping combined with classical microbiological tests fails to provide clinically informative information. Here, we use genomics to provide the first high-resolution view of this serotype, placing it into a wider genomic context of the Salmonella enterica species. These analyses reveal why it has been impossible to subdivide this serotype based upon phenotypic and limited molecular approaches. By examining the genomic data in detail, we are able to identify common features that correlate with strains of clinical importance. The results presented here provide new diagnostic targets, as well as posing important new questions about the basis for the invasive disease phenotype observed in a subset of strains.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||
Library of Congress Subject Headings (LCSH): | Salmonella -- Genetic aspects, Gene mapping | |||||||||
Journal or Publication Title: | mBio | |||||||||
Publisher: | American Society for Microbiology | |||||||||
ISSN: | 2150-7511 | |||||||||
Official Date: | 23 August 2016 | |||||||||
Dates: |
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Volume: | 7 | |||||||||
Number: | 4 | |||||||||
Page Range: | e00527-16 | |||||||||
DOI: | 10.1128/mBio.00527-16 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 1 February 2018 | |||||||||
Date of first compliant Open Access: | 1 February 2018 | |||||||||
RIOXX Funder/Project Grant: |
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