UNSPECIFIED. (2003) The effects of labour and of interleukin 1 beta upon the expression of nuclear factor kappa B related proteins in human amnion. MOLECULAR HUMAN REPRODUCTION, 9 (4). pp. 213-218. ISSN 1360-9947

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Abstract

Human labour is associated with persistently increased nuclear factor kappa 13 (NF-kB) activity in amnion. In this study we have shown that this involves only the p65 and p50 NF-kB subunits and is associated with an increase in the expression of p65 (P < 0.05), and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2 (P < 6.05). Interleukin-1b stimulation leads to rapid degradation and resynthesis of IkBa within 2 It, and a decrease in IkBb-1 without a return to full expression by 2 h, but has little effect upon IkBb-2. IkBb-2 was found in both the cytosolic and nuclear protein fractions. These findings demonstrate that persistently increased NF-kB activity in amnion occurs despite increased expression of the inhibitory IkBa protein and is not mediated by persistant I-kappa kinase activity or inhibition of IkBa synthesis. The increased expression and nuclear localization of IkBb-2 suggests that its function may be to protect NF-kB from inactivation by IkBa and to maintain NF-kB-mediated gene. transcription.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RG Gynecology and obstetrics
Journal or Publication Title:	MOLECULAR HUMAN REPRODUCTION
Publisher:	OXFORD UNIV PRESS
ISSN:	1360-9947
Date:	April 2003
Volume:	9
Number:	4
Number of Pages:	6
Page Range:	pp. 213-218
Identification Number:	10.1093/molehr/gag026
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9828

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