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Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis

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Irvine, Michael Alastair, Kazura, James W., Hollingsworth, T. Déirdre and Reimer, Lisa J. (2018) Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis. Proceedings of the Royal Society B: Biological Sciences, 285 (1871). 20172253. doi:10.1098/rspb.2017.2253 ISSN 0962-8452.

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Official URL: http://dx.doi.org/10.1098/rspb.2017.2253

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Abstract

It is well known that individuals in the same community can be exposed to a highly variable number of mosquito bites. This heterogeneity in bite exposure has consequences for the control of vector-borne diseases because a few people may be contributing significantly to transmission. However, very few studies measure sources of heterogeneity in a way which is relevant to decision-making. We investigate the relationship between two classic measures of heterogeneity, spatial and individual, within the context of lymphatic filariasis, a parasitic mosquito-borne disease. Using infection and mosquito-bite data for five villages in Papua New Guinea, we measure biting characteristics to model what impact bed-nets have had on control of the disease. We combine this analysis with geospatial modelling to understand the spatial relationship between disease indicators and nightly mosquito bites. We found a weak association between biting and infection heterogeneity within villages. The introduction of bed-nets increased biting heterogeneity, but the reduction in mean biting more than compensated for this, by reducing prevalence closer to elimination thresholds. Nightly biting was explained by a spatial heterogeneity model, while parasite load was better explained by an individual heterogeneity model. Spatial and individual heterogeneity are qualitatively different with profoundly different policy implications.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Elephantiasis -- Prevention, Mosquitoes as carriers of disease
Journal or Publication Title: Proceedings of the Royal Society B: Biological Sciences
Publisher: The Royal Society Publishing
ISSN: 0962-8452
Official Date: 31 January 2018
Dates:
DateEvent
31 January 2018Published
8 January 2018Accepted
Volume: 285
Number: 1871
Article Number: 20172253
DOI: 10.1098/rspb.2017.2253
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 2 February 2018
Date of first compliant Open Access: 2 February 2018
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDNational Institutes of Healthhttp://dx.doi.org/10.13039/100000002
UNSPECIFIEDBill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865

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