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Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis
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Irvine, Michael Alastair, Kazura, James W., Hollingsworth, T. Déirdre and Reimer, Lisa J. (2018) Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis. Proceedings of the Royal Society B: Biological Sciences, 285 (1871). 20172253. doi:10.1098/rspb.2017.2253 ISSN 0962-8452.
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WRAP-Understanding-heterogeneities-mosquito-bite-filariasis-Hollingsworth-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1150Kb) | Preview |
Official URL: http://dx.doi.org/10.1098/rspb.2017.2253
Abstract
It is well known that individuals in the same community can be exposed to a highly variable number of mosquito bites. This heterogeneity in bite exposure has consequences for the control of vector-borne diseases because a few people may be contributing significantly to transmission. However, very few studies measure sources of heterogeneity in a way which is relevant to decision-making. We investigate the relationship between two classic measures of heterogeneity, spatial and individual, within the context of lymphatic filariasis, a parasitic mosquito-borne disease. Using infection and mosquito-bite data for five villages in Papua New Guinea, we measure biting characteristics to model what impact bed-nets have had on control of the disease. We combine this analysis with geospatial modelling to understand the spatial relationship between disease indicators and nightly mosquito bites. We found a weak association between biting and infection heterogeneity within villages. The introduction of bed-nets increased biting heterogeneity, but the reduction in mean biting more than compensated for this, by reducing prevalence closer to elimination thresholds. Nightly biting was explained by a spatial heterogeneity model, while parasite load was better explained by an individual heterogeneity model. Spatial and individual heterogeneity are qualitatively different with profoundly different policy implications.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Elephantiasis -- Prevention, Mosquitoes as carriers of disease | |||||||||
| Journal or Publication Title: | Proceedings of the Royal Society B: Biological Sciences | |||||||||
| Publisher: | The Royal Society Publishing | |||||||||
| ISSN: | 0962-8452 | |||||||||
| Official Date: | 31 January 2018 | |||||||||
| Dates: |
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| Volume: | 285 | |||||||||
| Number: | 1871 | |||||||||
| Article Number: | 20172253 | |||||||||
| DOI: | 10.1098/rspb.2017.2253 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 2 February 2018 | |||||||||
| Date of first compliant Open Access: | 2 February 2018 | |||||||||
| RIOXX Funder/Project Grant: |
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