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Harnessing genomics to improve outcomes for women with cancer in India : key priorities for research
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Sundar, Sudha, Khetrapal-Singh, Poonam, Frampton, Jon, Trimble, Edward, Rajaraman, Preetha, Mehrotra, Ravi, Hariprasad, Roopa, Maitra, Arindam, Gill, Paramjit, Suri, Vanita, Srinivasan, Radhika, Singh, Gurpreet, Thakur, J. S., Dhillon, Preet and Cazier, Jean-Baptiste (2018) Harnessing genomics to improve outcomes for women with cancer in India : key priorities for research. The Lancet Oncology, 19 (2). e102-e112. doi:10.1016/S1470-2045(17)30726-X
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Official URL: http://dx.doi.org/10.1016/S1470-2045(17)30726-X
Abstract
Cumulatively, breast, cervical, ovarian, and uterine cancer account for more than 70% of cancers in women in India. Distinct differences in the clinical presentation of women with cancer suggest underlying differences in cancer biology and genetics. The peak age of onset of breast and ovarian cancer appears to be a decade earlier in India (age 45–50 years) than in high-income countries (age >60 years). Understanding these differences through research to develop diagnosis, screening, prevention, and treatment frameworks that ar e specific to the Indian population are critical and essential to improving women's health in India. Since the sequencing of the human genome in 2001, applications of advanced technologies, such as massively parallel sequencing, have transformed the understanding of the genetic and environmental drivers of cancer. How can advanced technologies be harnessed to provide health-care solutions at a scale and to a budget suitable for a country of 1·2 billion people? What research programmes are necessary to answer questions specific to India, and to build capacity for innovative solutions using these technologies? In order to answer these questions, we convened a workshop with key stakeholders to address these issues. In this Series paper, we highlight challenges in tackling the growing cancer burden in India, discuss ongoing genomics research and developments in infrastructure, and suggest key priorities for future research in cancer in India.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Social Science & Systems in Health (SSSH) Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Cancer -- Research., Cancer in women., Cancer in women -- India -- Prevention., Cancer in women -- Treatment -- India. | ||||||
| Journal or Publication Title: | The Lancet Oncology | ||||||
| Publisher: | The Lancet Publishing Group | ||||||
| ISSN: | 1470-2045 | ||||||
| Official Date: | 1 February 2018 | ||||||
| Dates: |
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| Volume: | 19 | ||||||
| Number: | 2 | ||||||
| Page Range: | e102-e112 | ||||||
| DOI: | 10.1016/S1470-2045(17)30726-X | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| RIOXX Funder/Project Grant: |
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