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The amyloid precursor-like protein 2 and the adenoviral E3/19K protein both bind to a conformational site on H-2K(d) and regulate H-2K(d) expression
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UNSPECIFIED. (2003) The amyloid precursor-like protein 2 and the adenoviral E3/19K protein both bind to a conformational site on H-2K(d) and regulate H-2K(d) expression. JOURNAL OF BIOLOGICAL CHEMISTRY, 278 (15). pp. 12618-12623. ISSN 0021-9258
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Official URL: http://dx.doi.org/10.1074/jbc.M208203200
Abstract
A protein of unknown physiological function, called amyloid precursor-like protein 2 (APLP2), forms an association with the murine class I molecule K-d that is up-regulated by the presence of the adenoviral protein E3/19K. We have extended these findings to show that APLP2 and E3/19K associate preferentially with folded Kd and not with the open form. APLP2 was detectable at the cell surface, but its surface expression was not upregulated by the concurrent expression of K-d. Experimental down-regulation of APLP2 expression caused a consistent increase in the surface expression of K-d, indicating that APLP2 normally reduces K-d surface expression. These data suggest a role for APLP2 in controlling the maturation of major histocompatibility complex class I molecules.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Journal or Publication Title: | JOURNAL OF BIOLOGICAL CHEMISTRY |
| Publisher: | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| ISSN: | 0021-9258 |
| Date: | 11 April 2003 |
| Volume: | 278 |
| Number: | 15 |
| Number of Pages: | 6 |
| Page Range: | pp. 12618-12623 |
| Identification Number: | 10.1074/jbc.M208203200 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/9833 |
Data sourced from Thomson Reuters' Web of Knowledge
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