The Library
The association between idiopathic thrombocytopenic purpura and cardiovascular disease : a retrospective cohort study
Tools
Tools
Tools
Chandan, J. S., Thomas, T., Lee, S., Marshall, T., Willis, B., Nirantharakumar, Krishnarajah and Gill, Paramjit (2018) The association between idiopathic thrombocytopenic purpura and cardiovascular disease : a retrospective cohort study. Journal of Thrombosis and Haemostasis . doi:10.1111/jth.13940 ISSN 1538-7933.
|
PDF
WRAP-association-idiopathic-thrombocytopenic-purpura-disease-Gill-2018.pdf - Accepted Version - Requires a PDF viewer. Download (811Kb) | Preview |
Official URL: http://dx.doi.org/10.1111/jth.13940
Abstract
Background
Idiopathic thrombocytopenic purpura (ITP) is classically characterized by a transient or persistent decrease of platelet count. Mortality is higher in the ITP population than the general population, with a possible association with increased cardiovascular disease (CVD).
Objectives
The objective was to assess the strength of the association between ITP and CVD, with a secondary aim to assess the impact of splenectomy on CVD.
Methods
A population-based retrospective, open cohort study using clinical codes was performed using data from 6591 patients with ITP and 24 275 randomly matched controls (up to 1:4 ratio matched by age, sex, body mass index and smoking status). The main outcome was the risk of CVD, which included ischemic heart disease, stroke, trans-ischemic attack and heart failure. Adjusted incidence rate ratios were calculated using Poisson regression.
Results
During a median 6-year observation period there was a CVD diagnosis recorded in 392 (5.9%) ITP patients and 1114 (4.5%) control patients. There was an increased risk of developing CVD in the ITP cohort (incidence rate ratio [IRR], 1.38; 95% confidence interval [CI], 1.23–1.55), which remained robust even after a sensitivity analysis only including incident cases of ITP. Findings suggested that patients who had undergone splenectomy were at even further increased risk of developing CVD when compared with the ITP population who had not undergone splenectomy (adjusted IRR, 1.69; 95% CI, 1.22–2.34).
Conclusion
There is an increased risk of developing CVD in patients with ITP and even further increased risk for those patients with ITP who underwent splenectomy.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
| Library of Congress Subject Headings (LCSH): | Cardiovascular system -- Diseases, Thrombotic thrombocytopenic purpura | ||||||
| Journal or Publication Title: | Journal of Thrombosis and Haemostasis | ||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||
| ISSN: | 1538-7933 | ||||||
| Official Date: | 5 January 2018 | ||||||
| Dates: |
|
||||||
| DOI: | 10.1111/jth.13940 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 6 February 2018 | ||||||
| Date of first compliant Open Access: | 7 November 2018 |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
