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Sugar-coated amphiphilic block copolymer micelles from living radical polymerization: Recognition by immobilized lectins

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UNSPECIFIED. (2003) Sugar-coated amphiphilic block copolymer micelles from living radical polymerization: Recognition by immobilized lectins. MACROMOLECULES, 36 (7). pp. 2493-2499. ISSN 0024-9297

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Abstract

Block copolymers poly[((ethylene glycol)methyl ether methaerylate)-b-(benzyl methacrylate)] containing protected sugar groups were synthesized by transition-metal-mediated living radical polymerization. Sugar-derived initiators were prepared by esterification of the hydroxyl group of isopropylidene-protected galactose and glucose with 2-bromoisobutyryl bromide. Both protected galactose and glucose-derived initiators were respectively used to initiate the hydrophilic monomer (PEGMA) and the hydrophobic monomer (BzMA) in both one-pot and two-step polymerizations. In both cases the polymerization occurred with good first-order kinetics, producing AB blocks with molecular weights close to that targeted and with low polydispersity (1.1-1.2). Following removal of the isopropylidene protective groups via acidolysis with 50% trifluoroacetic acid (TFA) at ambient temperature, block copolymer micelles were obtained by a dialysis solvent exchange process. The size and polydispersity of the polymer micelle were estimated by dynamic light scattering, and the Z-averaged hydrodynamic diameters were found to be between 35 and 41 nm with a unimodal size distribution. Furthermore, the binding ability of a galactose bearing copolymer micelles was confirmed by recognition with an HPLC column packed with immobilized RCA-1 lectin.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Journal or Publication Title: MACROMOLECULES
Publisher: AMER CHEMICAL SOC
ISSN: 0024-9297
Date: 8 April 2003
Volume: 36
Number: 7
Number of Pages: 7
Page Range: pp. 2493-2499
Identification Number: 10.1021/ma0211986
Publication Status: Published
URI: http://wrap.warwick.ac.uk/id/eprint/9852

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