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Twisted protein aggregates and disease: The stability of sickle hemoglobin fibers
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UNSPECIFIED. (2003) Twisted protein aggregates and disease: The stability of sickle hemoglobin fibers. PHYSICAL REVIEW LETTERS, 90 (12). -. ISSN 0031-9007
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Official URL: http://dx.doi.org/10.1103/PhysRevLett.90.128103
Abstract
We describe how twist could play an essential role in stabilizing 20 nm diameter sickle hemoglobin fibers. Our theory successfully reproduces the observed variation of helical pitch length with fiber diameter. With no remaining adjustable parameters it also yields a prediction for the torsional rigidity of sickle hemoglobin fibers that is in good agreement with experiment and hence retains the striking feature that such fibers can be highly mechanically anisotropic, even with a ratio of bending to torsional rigidity of about 50. We discuss how our study might be relevant to the development of treatment strategies.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QC Physics |
| Journal or Publication Title: | PHYSICAL REVIEW LETTERS |
| Publisher: | AMERICAN PHYSICAL SOC |
| ISSN: | 0031-9007 |
| Date: | 28 March 2003 |
| Volume: | 90 |
| Number: | 12 |
| Number of Pages: | 4 |
| Page Range: | - |
| Identification Number: | 10.1103/PhysRevLett.90.128103 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/9870 |
Data sourced from Thomson Reuters' Web of Knowledge
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