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Host protein BSL1 associates with phytophthora infestans RXLR effector AVR2 and the solanum demissum immune receptor R2 to mediate disease resistance
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Saunders, D. G. O., Breen, Susan, Win, J., Schornack, S., Hein, I., Bozkurt, T. O., Champouret, N., Vleeshouwers, V. G. A. A., Birch, P. R. J., Gilroy, E. M. and Kamoun, S. (2012) Host protein BSL1 associates with phytophthora infestans RXLR effector AVR2 and the solanum demissum immune receptor R2 to mediate disease resistance. The Plant Cell, 24 (8). pp. 3420-3434. doi:10.1105/tpc.112.099861 ISSN 1040-4651.
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Official URL: http://dx.doi.org/10.1105/tpc.112.099861
Abstract
Antimicrobial peptides (AMPs) are natural products found across diverse taxa as part of the innate immune system against pathogen attacks. Some AMPs are synthesized through the canonical gene expression machinery and are called ribosomal AMPs. Other AMPs are assembled by modular enzymes generating nonribosomal AMPs and harbor unusual structural diversity. Plants synthesize an array of AMPs, yet are still subject to many pathogen invasions. Crop breeding programs struggle to release new cultivars in which complete disease resistance is achieved, and usually such resistance becomes quickly overcome by the targeted pathogens which have a shorter generation time. AMPs could offer a solution by exploring not only plant-derived AMPs, related or unrelated to the crop of interest, but also non-plant AMPs produced by bacteria, fungi, oomycetes or animals. This review highlights some promising candidates within the plant kingdom and elsewhere, and offers some perspectives on how to identify and validate their bioactivities. Technological advances, particularly in mass spectrometry (MS) and nuclear magnetic resonance (NMR), have been instrumental in identifying and elucidating the structure of novel AMPs, especially nonribosomal peptides which cannot be identified through genomics approaches. The majority of non-plant AMPs showing potential for plant disease immunity are often tested using in vitro assays. The greatest challenge remains the functional validation of candidate AMPs in plants through transgenic experiments, particularly introducing nonribosomal AMPs into crops.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | The Plant Cell | ||||
Publisher: | American Society of Plant Biologists | ||||
ISSN: | 1040-4651 | ||||
Official Date: | 2012 | ||||
Dates: |
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Volume: | 24 | ||||
Number: | 8 | ||||
Page Range: | pp. 3420-3434 | ||||
DOI: | 10.1105/tpc.112.099861 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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