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Loss of AvrSr50by somatic exchange in stem rust leads to virulence for Sr50 resistance in wheat

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Chen, Jiapeng, Upadhyaya, Narayana M., Ortiz, Diana, Sperschneider, Jana, Li, Feng, Bouton, Clement, Breen, Susan, Dong, Chongmei, Xu, Bo, Zhang, Xiaoxiao et al.
(2017) Loss of AvrSr50by somatic exchange in stem rust leads to virulence for Sr50 resistance in wheat. Science, 358 (6370). pp. 1607-1610. doi:10.1126/science.aao4810

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Official URL: http://dx.doi.org/10.1126/science.aao4810

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Abstract

Race-specific resistance genes protect the global wheat crop from stem rust disease caused by Puccinia graminis f. sp. tritici (Pgt) but are often overcome owing to evolution of new virulent races of the pathogen. To understand virulence evolution in Pgt, we identified the protein ligand (AvrSr50) recognized by the Sr50 resistance protein. A spontaneous mutant of Pgt virulent to Sr50 contained a 2.5 mega–base pair loss-of-heterozygosity event. A haustorial secreted protein from this region triggers Sr50-dependent defense responses in planta and interacts directly with the Sr50 protein. Virulence alleles of AvrSr50 have arisen through DNA insertion and sequence divergence, and our data provide molecular evidence that in addition to sexual recombination, somatic exchange can play a role in the emergence of new virulence traits in Pgt.

Item Type: Journal Article
Divisions: Faculty of Science > Life Sciences (2010- )
Journal or Publication Title: Science
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Official Date: 22 December 2017
Dates:
DateEvent
22 December 2017Published
3 November 2017Accepted
Volume: 358
Number: 6370
Page Range: pp. 1607-1610
DOI: 10.1126/science.aao4810
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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