UNSPECIFIED (2003) IgG subclass responses in a longitudinal study of canine visceral leishmaniasis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 91 (3-4). pp. 161-168. ISSN 0165-2427

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Abstract

Visceral leishmaniasis (VL), caused by Leishmania infantum, is an important disease of domestic dogs. Here, we present data on the IgG subclass antibody response to crude L infantum antigen in a cohort of naturally infected Brazilian dogs. Specific IgG1-IgG4 responses could be detected in 98, 58, 70 and 82%, respectively of 57 dogs that were seropositive for specific IgG. Levels of all IgG subclasses were strongly inter-correlated. Levels of all IgG subclasses increased at the time of seroconversion, before reaching a plateau after several months. Levels of all IgG subclasses were higher in sick dogs than healthy dogs, and levels of all except IgG2 were higher in parasite-positive (by PCR) than parasite-negative dogs. However, levels of IgG2 relative to IgG1 were lower in sick or parasite-positive dogs compared to healthy or parasite-negative infected dogs. In contrast to previous studies, the results suggest that canine VL is associated with upregulation of specific antibody of all IgG subclasses, particularly IgG1, IgG3 and IgG4. (C) 2002 Elsevier Science B.V. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology S Agriculture > SF Animal culture
Journal or Publication Title:	VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0165-2427
Date:	10 February 2003
Volume:	91
Number:	3-4
Number of Pages:	8
Page Range:	pp. 161-168
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/9970

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