Redundant early and overlapping larval roles of Xsox17 subgroup genes in Xenopus endoderm development
UNSPECIFIED. (2003) Redundant early and overlapping larval roles of Xsox17 subgroup genes in Xenopus endoderm development. MECHANISMS OF DEVELOPMENT, 120 (3). pp. 337-348. ISSN 0925-4773Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/S0925-4773(02)00450-1
We have used antisense morpholino oligos to establish the developmental roles of three Xsox17 proteins in Xenopus development (Xsox17alpha(1), alpha(2) and beta). We show that their synthesis can be inhibited with modest amounts of oligo. The inhibition of each individually produces defects in late midgut development. Loss of activity of the Xsox17alpha proteins additionally inhibits hindgut formation, and inhibiting Xsox17alpha I disrupts foregut development with variable penetrance. When all Xsox17 activity is inhibited cell movements are halted during late gastrulation and the transcription of several endodermally expressed genes is reduced. Thus the Xsox17 proteins have redundant roles in early development of the endoderm and partly distinct roles during later organogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||MECHANISMS OF DEVELOPMENT|
|Publisher:||ELSEVIER SCIENCE BV|
|Official Date:||March 2003|
|Number of Pages:||12|
|Page Range:||pp. 337-348|
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