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Iodine status during pregnancy in a region of mild-to-moderate iodine deficiency is not associated with adverse obstetric outcomes ; results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
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Torlinska, Barbara, Bath, Sarah C., Janjua, Aisha, Boelaert, Kristien and Chan, Shiao-Yng (2018) Iodine status during pregnancy in a region of mild-to-moderate iodine deficiency is not associated with adverse obstetric outcomes ; results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Nutrients, 10 (3). 291. doi:10.3390/nu10030291
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Official URL: https://doi.org/10.3390/nu10030291
Abstract
Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine concentration of 95.3 µg/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 µg/g, IQR 82–198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 µg/g). The incidence of pre-eclampsia, non-proteinuric gestational hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required. View Full-Text
| Item Type: | Journal Article | ||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Journal or Publication Title: | Nutrients | ||||||
| Publisher: | M D P I A G | ||||||
| ISSN: | 2072-6643 | ||||||
| Official Date: | 1 March 2018 | ||||||
| Dates: |
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| Date of first compliant deposit: | 19 September 2018 | ||||||
| Volume: | 10 | ||||||
| Number: | 3 | ||||||
| Article Number: | 291 | ||||||
| DOI: | 10.3390/nu10030291 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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