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Alternative splicing associated with phenotypic plasticity in the bumble bee Bombus terrestris

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Price, Jonathan, Harrison, M. C., Hammond, R. L., Adams, S. (Stefan), Gutierrez-Marcos, José F. and Mallon, E. B. (2018) Alternative splicing associated with phenotypic plasticity in the bumble bee Bombus terrestris. Molecular Ecology, 27 (4). pp. 1036-1043. doi:10.1111/mec.14495

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Official URL: http://dx.doi.org/10.1111/mec.14495

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Abstract

Phenotypic plasticity is when one genome can produce more than one phenotype. The caste system found in many social insects is an important example of plasticity. Several studies have examined gene expression in social insect developmental and caste differences. Changes in gene expression, however, are not the only source of phenotypic plasticity. Here, we investigate the role of alternative splicing in the buff-tailed bumble bee Bombus terrestris. We found that 5,458 genes in B. terrestris (40%) express more than one isoform. Larvae have the lowest level of splicing events, followed by adults and then pupae. We found that when an isoform is expressed in a given caste in the larval stage, it tends to be expressed in all castes at the larval stage. The same is true at the pupal stage. However, we see more complicated interactions between the adult castes with reproductive females showing different isoform expression compared to nonreproductive females and male adults showing the most distinct patterns. We found 455 isoform switching genes, that is genes, where one developmental stage, sex or caste uses a specific isoform and another type uses a different isoform. Among genes displaying isoform switching are some involved in the ecdysteriod pathway, an important system in insect behaviour.

Item Type: Journal Article
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Phenotypic plasticity., Bumblebees -- Behavior, Genomes.
Journal or Publication Title: Molecular Ecology
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0962-1083
Official Date: 11 February 2018
Dates:
DateEvent
11 February 2018Published
29 January 2018Available
17 January 2018Accepted
Volume: 27
Number: 4
Page Range: pp. 1036-1043
DOI: 10.1111/mec.14495
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIED[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
NE/N010019/1[NERC] Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270
NBAF 829[NERC] Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270
R8/H10/56[NERC] Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270
MR/K001744/1[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
BB/J004243/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
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