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Alternative splicing associated with phenotypic plasticity in the bumble bee Bombus terrestris
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Price, Jonathan, Harrison, M. C., Hammond, R. L., Adams, S. (Stefan), Gutierrez-Marcos, José F. and Mallon, E. B. (2018) Alternative splicing associated with phenotypic plasticity in the bumble bee Bombus terrestris. Molecular Ecology, 27 (4). pp. 1036-1043. doi:10.1111/mec.14495
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WRAP-alternative-splicing-associated-phenotypic-Gutierrez-Marcos-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1215Kb) | Preview |
Official URL: http://dx.doi.org/10.1111/mec.14495
Abstract
Phenotypic plasticity is when one genome can produce more than one phenotype. The caste system found in many social insects is an important example of plasticity. Several studies have examined gene expression in social insect developmental and caste differences. Changes in gene expression, however, are not the only source of phenotypic plasticity. Here, we investigate the role of alternative splicing in the buff-tailed bumble bee Bombus terrestris. We found that 5,458 genes in B. terrestris (40%) express more than one isoform. Larvae have the lowest level of splicing events, followed by adults and then pupae. We found that when an isoform is expressed in a given caste in the larval stage, it tends to be expressed in all castes at the larval stage. The same is true at the pupal stage. However, we see more complicated interactions between the adult castes with reproductive females showing different isoform expression compared to nonreproductive females and male adults showing the most distinct patterns. We found 455 isoform switching genes, that is genes, where one developmental stage, sex or caste uses a specific isoform and another type uses a different isoform. Among genes displaying isoform switching are some involved in the ecdysteriod pathway, an important system in insect behaviour.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||||||||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | |||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Phenotypic plasticity., Bumblebees -- Behavior, Genomes. | |||||||||||||||||||||
| Journal or Publication Title: | Molecular Ecology | |||||||||||||||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | |||||||||||||||||||||
| ISSN: | 0962-1083 | |||||||||||||||||||||
| Official Date: | 11 February 2018 | |||||||||||||||||||||
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| Date of first compliant deposit: | 14 March 2018 | |||||||||||||||||||||
| Volume: | 27 | |||||||||||||||||||||
| Number: | 4 | |||||||||||||||||||||
| Page Range: | pp. 1036-1043 | |||||||||||||||||||||
| DOI: | 10.1111/mec.14495 | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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