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Screening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours : a cross-sectional study
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Qureshi, Sheharyar A., Burch, Nicola, Druce, Maralyn, Hattersley, John G, Khan, Saboor, Gopalakrishnan, Kishore, Darby, Catherine, Wong, John L H, Davies, Louise, Fletcher, Simon, Shatwell, William, Sothi, Sharmila, Randeva, Harpal S., Dimitriadis, Georgios K. and Weickert, Martin O. (2016) Screening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours : a cross-sectional study. BMJ Open, 6 (5). e010765. doi:10.1136/bmjopen-2015-010765 ISSN 2044-6055.
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Official URL: http://dx.doi.org/10.1136/bmjopen-2015-010765
Abstract
Objectives To investigate whether screening for malnutrition using the validated malnutrition universal screening tool (MUST) identifies specific characteristics of patients at risk, in patients with gastro-entero-pancreatic neuroendocrine tumours (GEP-NET).
Design Cross-sectional study.
Setting University Hospitals Coventry & Warwickshire NHS Trust; European Neuroendocrine Tumour Society Centre of Excellence.
Participants Patients with confirmed GEP-NET (n=161) of varying primary tumour sites, functioning status, grading, staging and treatment modalities.
Main outcome measure To identify disease and treatment-related characteristics of patients with GEP-NET who score using MUST, and should be directed to detailed nutritional assessment.
Results MUST score was positive (≥1) in 14% of outpatients with GEP-NET. MUST-positive patients had lower faecal elastase concentrations compared to MUST-negative patients (244±37 vs 383±20 µg/g stool; p=0.018), and were more likely to be on treatment with long-acting somatostatin analogues (65 vs 38%, p=0.021). MUST-positive patients were also more likely to have rectal or unknown primary NET, whereas, frequencies of other GEP-NET including pancreatic NET were comparable between MUST-positive and MUST-negative patients.
Conclusions Given the frequency of patients identified at malnutrition risk using MUST in our relatively large and diverse GEP-NET cohort and the clinical implications of detecting malnutrition early, we recommend routine use of malnutrition screening in all patients with GEP-NET, and particularly in patients who are treated with long-acting somatostatin analogues.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
Library of Congress Subject Headings (LCSH): | Gastrointestinal system -- Tumors, Malnutrition, Medical screening | ||||||
Journal or Publication Title: | BMJ Open | ||||||
Publisher: | BMJ | ||||||
ISSN: | 2044-6055 | ||||||
Official Date: | 4 May 2016 | ||||||
Dates: |
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Volume: | 6 | ||||||
Number: | 5 | ||||||
Article Number: | e010765 | ||||||
DOI: | 10.1136/bmjopen-2015-010765 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 21 March 2018 | ||||||
Date of first compliant Open Access: | 22 March 2018 | ||||||
RIOXX Funder/Project Grant: |
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