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Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone
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UNSPECIFIED (2002) Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone. EUROPEAN JOURNAL OF PHARMACOLOGY, 441 (3). pp. 193-202. ISSN 0014-2999.
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Abstract
The two kinin receptors, B-1 and B-2, are upregulated in inflammation and may play a role in diseases such as asthma. In pulmonary A549 cells, TNF-alpha or interleukin-1beta dramatically increased bradykinin B-1 and B-2 receptor mRNA expression and this response was prevented by dexamethasone. In primary human bronchial epithelial cells, bradykinin B-1 receptor mRNA expression showed a similar trend, whereas bradykinin B-2 receptor showed almost constitutive expression. Radioligand-binding studies revealed significant increases in bradykinin B-1 receptor protein expression following both interleukin-1beta and TNF-alpha treatment of A549 cells; however, no evidence was found for bradykinin B-1 receptor. Functionally, the bradykinin B-2 receptor ligand, bradykinin, but not the B-1 ligand, des-Arg(10)-kallidin, produced a marked increase in prostaglandin E-2 release when administered following interleukin-1beta treatment. Arachidonic acid release in response to bradykinin was markedly enhanced by prior incubation with interleukin-1beta and this was prevented by the prior addition of dexamethasone. (C) 2002 Elsevier Science B.V. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RS Pharmacy and materia medica | ||||
Journal or Publication Title: | EUROPEAN JOURNAL OF PHARMACOLOGY | ||||
Publisher: | ELSEVIER SCIENCE BV | ||||
ISSN: | 0014-2999 | ||||
Official Date: | 26 April 2002 | ||||
Dates: |
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Volume: | 441 | ||||
Number: | 3 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 193-202 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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