The Library
Synthesis and in vitro enzyme activity of an oxa analogue of azi-DAP
Tools
UNSPECIFIED (2002) Synthesis and in vitro enzyme activity of an oxa analogue of azi-DAP. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (8). pp. 1029-1035. doi:10.1039/b201727j ISSN 1472-7781.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1039/b201727j
Abstract
The synthesis of a novel epoxide inhibitor 6 of meso-DAP epimerase was achieved. A new and convenient assay for meso-DAP epimerase was devised which is a considerable improvement on previously reported assay methods. This assay was used to determine the inhibitory properties of 6. The epoxide 6 shows limited competitive inhibition vs. meso-DAP epimerase, but clear time dependent inhibition indicative of the expected covalent attachment at the active site. Epoxide 6, although an effective inhibitor of meso-DAP epimerase, was unstable at pH 7.3 in aqueous buffer, being hydrolysed to the corresponding diol.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | ||||
Publisher: | ROYAL SOC CHEMISTRY | ||||
ISSN: | 1472-7781 | ||||
Official Date: | 2002 | ||||
Dates: |
|
||||
Number: | 8 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 1029-1035 | ||||
DOI: | 10.1039/b201727j | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |