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Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro
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UNSPECIFIED (2001) Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 108 (9). pp. 960-966. ISSN 0306-5456.
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Abstract
Objectives To determine whether: 1. oxytocin receptor antagonists influence spontaneous contractions of myometrium from humans, non-human primates and rodents (in vitro), and 2. vasopressin V-1a receptor antagonism is important for inhibition of spontaneous contractions in human myometrium.
Design In vitro pharmacology of spontaneous contractions of myometrium from humans and animals.
Setting The research laboratories of a university department of obstetrics and gynaecology and a pharmaceutical industry research centre.
Interventions Samples of human myometrium were obtained at caesarean section. Tissue strips were suspended in organ baths for isometric force recording. Cumulative concentration effect curves to a selective oxytocin receptor antagonist (L-371,257) and a mixed oxytocin/vasopressin V-1a receptor antagonist (atosiban) were obtained. The effect of L-371,257 was also determined in myometrium from non-pregnant rats and marmosets.
Main outcome measures The inhibition of spontaneous myometrial contractions in vitro.
Results L-371,257 and atosiban significantly inhibited spontaneous activity of human myometrium in a concentration-related manner (P < 0.05), although the effect was more pronounced with L-371,257. Spontaneous contractions of myometrium from non-pregnant rats and marmosets were also inhibited by L-371,257 (atosiban was not tested).
Conclusions Spontaneous contractions of myometrium from humans, marmosets and rats are, at least in part, dependent on oxytocin receptor activity, in vitro. L-371,257 and atosiban may be inverse agonists. Selective non-peptide oxytocin receptor antagonists may be effective tocolytics.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
Journal or Publication Title: | BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | ||||
Publisher: | ELSEVIER SCIENCE BV | ||||
ISSN: | 0306-5456 | ||||
Official Date: | September 2001 | ||||
Dates: |
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Volume: | 108 | ||||
Number: | 9 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 960-966 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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