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CD40 ligand, Bcl-2, and Bcl-x(L) spare group I Burkitt lymphoma cells from CD77-directed killing via Verotoxin-1 B chain but fail to protect against the holotoxin
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UNSPECIFIED (2000) CD40 ligand, Bcl-2, and Bcl-x(L) spare group I Burkitt lymphoma cells from CD77-directed killing via Verotoxin-1 B chain but fail to protect against the holotoxin. CELL DEATH AND DIFFERENTIATION, 7 (9). pp. 785-794. ISSN 1350-9047.
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Abstract
Owing to its lineage and differentiation stage-restricted expression, CD77 has been mooted as a therapeutic target in Burkitt lymphoma (BL). The recognition that the globotriaosyl moiety of this neutral glycosphingolipid is a receptor for Escherichia coli derived Verotoxin-1 (Shiga-Like Toxin-1) offers a potential delivery system for the attack, Here we show that CD77-expressing Group I BL cells which are normally susceptible to activation-induced death on binding Verotoxin-1 B chain are protected in the presence of CD40 ligand, Ectopic expression of either bcl-2 or bcl-x(L) also afforded resistance to the actions of the B chain. In total contrast, neither of the survival genes nor a CD40 signal - even when acting in concert - protected against killing mediated by the holotoxin. These findings indicate that while therapeutic modalities for CD77-expressing B cell tumors (which include follicular lymphoma) based on the use of Verotoxin-1 B chain might be compromised by the activation of endogenous or exogenous survival pathways, those exploiting the holotoxin should be left unscathed.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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Journal or Publication Title: | CELL DEATH AND DIFFERENTIATION | ||||
Publisher: | NATURE PUBLISHING GROUP | ||||
ISSN: | 1350-9047 | ||||
Official Date: | September 2000 | ||||
Dates: |
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Volume: | 7 | ||||
Number: | 9 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 785-794 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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