The Library
Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast
Tools
UNSPECIFIED (1999) Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast. FEBS LETTERS, 459 (1). pp. 80-84. ISSN 0014-5793.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
Cytotoxic proteins such as ricin A chain (RTA) have target substrates in the cytosol and therefore hale to reach this cellular compartment in order to act. RTA is thought to translocate into the cytosol from the lumen of the endoplasmic reticulum (ER), although how it traverses the ER membrane has not been established, Using yeast mutants defective in various aspects of the ER-associated protein degradation (ER,ID) pathway, we shots that RTA introduced into the yeast ER subverts this pathway to enter the cytosol via the Sec61p translocon. A significant proportion of the exported RTA avoided proteasomal degradation. These data are consistent with the contention that the RTa component from ricin endocytosed by mammalian cells may likewise exploit ERAD to translocate into the cytosol. (C) 1999 Federation of European Biochemical Societies.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
||||
Journal or Publication Title: | FEBS LETTERS | ||||
Publisher: | ELSEVIER SCIENCE BV | ||||
ISSN: | 0014-5793 | ||||
Official Date: | 1 October 1999 | ||||
Dates: |
|
||||
Volume: | 459 | ||||
Number: | 1 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 80-84 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |