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Chemoenzymic synthesis of beta-D-gal(6-SO4)-(1 -> 4)-D-GlcNAc, beta-D-Gal-(1 -> 4)-D-GlcNAc(6-SO4)and beta-D-GlcNAc-(1 -> 4)-D-GlcNAc(6-SO4) and their roles as fucosyl acceptors in reactions catalysed by human alpha-3-fucosyltransferases
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UNSPECIFIED (1998) Chemoenzymic synthesis of beta-D-gal(6-SO4)-(1 -> 4)-D-GlcNAc, beta-D-Gal-(1 -> 4)-D-GlcNAc(6-SO4)and beta-D-GlcNAc-(1 -> 4)-D-GlcNAc(6-SO4) and their roles as fucosyl acceptors in reactions catalysed by human alpha-3-fucosyltransferases. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (15). pp. 2295-2299. ISSN 0300-922X.
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Abstract
N-Acetyllactosamine 5 is obtained by transglycoslyation between p-nitrophenyl beta-D-galactopyranoside 3 and N-acetyl-D-glucosamine 4 by using the beta-galactosidase from Bacillus circulans as the biocatalyst, Sodium salts of beta-Gal(6-SO4)-(1-->4)-GlcNAc 1 and beta-Gal-(1-->4)-GlcNAc(6-SO4) 2 have been prepared from N-acetyllactosamine 5 in five and three steps respectively. beta-D-GlcNAc-(1-->4)-D-GlcNAc(6-SO4) (di-N-acetylchitobiose 6-sulfate) 10 is synthesised from chitin in three steps. The products have been tested as fucosyl accepters in reactions catalysed by recombinant human fucosyltransferases III to VII.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | ||||
Publisher: | ROYAL SOC CHEMISTRY | ||||
ISSN: | 0300-922X | ||||
Official Date: | 7 August 1998 | ||||
Dates: |
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Number: | 15 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 2295-2299 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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