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Overlapping functions of components of a bacterial Sec-independent protein export pathway
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UNSPECIFIED (1998) Overlapping functions of components of a bacterial Sec-independent protein export pathway. EMBO JOURNAL, 17 (13). pp. 3640-3650. ISSN 0261-4189.
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Abstract
We describe the identification of two Escherichia coli genes required for the export of cofactor-containing periplasmic proteins, synthesized with signal peptides containing a twin arginine motif, Both gene products are homologous to the maize HCF106 protein required for the translocation of a subset of lumenal proteins across the thylakoid membrane. Disruption of either gene affects the export of a range of such proteins, and a complete block is observed when both genes are inactivated. The Sec protein export pathway was unaffected, indicating the involvement of the gene products in a novel export system. The accumulation of active cofactor-containing proteins in the cytoplasm of the mutant strains suggests a role for the gene products in the translocation of folded proteins. One of the two HCF106 homologues is encoded by the first gene of a four cistron operon, tatABCD, and the second by an unlinked gene, tatE, A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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Journal or Publication Title: | EMBO JOURNAL | ||||
Publisher: | OXFORD UNIV PRESS | ||||
ISSN: | 0261-4189 | ||||
Official Date: | 1 July 1998 | ||||
Dates: |
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Volume: | 17 | ||||
Number: | 13 | ||||
Number of Pages: | 11 | ||||
Page Range: | pp. 3640-3650 | ||||
Publication Status: | Published |
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