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Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse
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Lalo, Ulyana, Andrew, Jemma, Palygin, Oleg and Pankratov, Yuriy (2009) Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse. Biochemical Society Transactions, Vol.374 (Part 6). pp. 1407-1411. doi:10.1042/BST0371407 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST0371407
Abstract
The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of 'tripartite synapse'. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate and D-serine. one of the regulatory pathways in the tripartite synapse is mediated by P2X purinoreceptors. Release of ATP from synaptic terminals and astrocytes activates Ca2+ influx via P2X purinoreceptors which co-localize with NMDA (N-methyl-D-aspartate) and GABA (gamma-aminobutyric acid) receptors and can modulate their activity via intracellular cascades which involve phosphatase II and PKA (protein kinase A).
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Journal or Publication Title: | Biochemical Society Transactions | ||||
Publisher: | Portland Press Ltd | ||||
ISSN: | 0300-5127 | ||||
Official Date: | December 2009 | ||||
Dates: |
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Volume: | Vol.374 | ||||
Number: | Part 6 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 1407-1411 | ||||
DOI: | 10.1042/BST0371407 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
Grant number: | BB/F0221445 (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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