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Phosphine-mediated one-pot thiol–ene “click” approach to polymer–protein conjugates
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Jones, Mathew W., Mantovani, Giuseppe, Ryan, Sinead M., Wang, Xuexuan, Brayden, David J. and Haddleton, David M. (2009) Phosphine-mediated one-pot thiol–ene “click” approach to polymer–protein conjugates. Chemical Communications (No.35). pp. 5272-5274. doi:10.1039/b906865a ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/b906865a
Abstract
We employ water-soluble organic phosphines as key reagents in a one-pot synthetic protocol where a (poly)peptide disulfide bridge is first reduced followed by subsequent reaction of the two thiols in situ with poly(monomethoxy ethylene glycol)-(meth) acrylates (p(mPEG)(M)A); we use salmon calcitonin (sCT) as a disulfide bridge-containing peptide, which contains a disulfide bridge-Cys1-Cys7-that can be reduced to give two sulfhydryl units available for thiol functionalisation; bioactivity is retained.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Phosphine, Biomolecules, Bioconjugates, Conjugated polymers | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | September 2009 | ||||
Dates: |
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Number: | No.35 | ||||
Number of Pages: | 3 | ||||
Page Range: | pp. 5272-5274 | ||||
DOI: | 10.1039/b906865a | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | University of Warwick, Science Foundation Ireland (SFI), Advantage West Midlands (AWM), European Regional Development Fund (ERDF) | ||||
Grant number: | 04 IN3 B575 (SFI) |
Data sourced from Thomson Reuters' Web of Knowledge
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