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Nucleotide sequence of the gene encoding the viral polymerase of avian pneumovirus
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UNSPECIFIED (1996) Nucleotide sequence of the gene encoding the viral polymerase of avian pneumovirus. JOURNAL OF GENERAL VIROLOGY, 77 (Part 12). pp. 3047-3051. ISSN 0022-1317.
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Abstract
We report here the nucleotide sequence of the L gene of avian pneumovirus (APV). This is the second pneumovirus L gene and the second avian paramyxovirus L gene, following that of Newcastle disease virus, to be sequenced. The APV L gene is 6099 nucleotides long and encodes a single large ORF of 2004 amino acids. This makes the APV L protein the smallest to be described for any nonsegmented, negative-strand RNA virus. The protein contains six linear non-contiguous domains, a putative ATP-binding site and four polymerase motifs previously described for the L proteins of negative-strand RNA viruses. Phylogenetic analysis of domain III of 14 different L proteins suggests the pneumoviruses to be as distant in evolutionary terms from the other members of the Paramyxoviridae as are the Filoviridae.
Item Type: | Journal Article | ||||
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Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology |
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Journal or Publication Title: | JOURNAL OF GENERAL VIROLOGY | ||||
Publisher: | SOC GENERAL MICROBIOLOGY | ||||
ISSN: | 0022-1317 | ||||
Official Date: | December 1996 | ||||
Dates: |
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Volume: | 77 | ||||
Number: | Part 12 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 3047-3051 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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