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Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction
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Marrus, Scott B., Portman, Scott L., Allen, Marcus James, Moffat, Kevin G. and DiAntonio, Aaron (2004) Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction. Journal of Neuroscience, Vol.24 (No.6). pp. 1406-1415. doi:10.1523/JNEUROSCI.1575-03.2004 ISSN 0270-6474.
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Official URL: http://dx.doi.org/10.1523/JNEUROSCI.1575-03.2004
Abstract
The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular junction and are redundant for viability, yet differ in their physiological properties. We now identify a third glutamate receptor subunit at the Drosophila neuromuscular junction, DGluRIII, which is essential for viability. DGluRIII is required for the synaptic localization of DGluRIIA and DGluRIIB and for synaptic transmission. Either DGluRIIA or DGluRIIB, but not both, is required for the synaptic localization of DGluRIII. DGluRIIA and DGluRIIB compete with each other for access to DGluRIII and subsequent localization to the synapse. These results are consistent with a model of a multimeric receptor in which DGluRIII is an essential component. At single postsynaptic cells that receive innervation from multiple motoneurons, DGluRIII is abundant at all synapses. However, DGluRIIA and DGluRIIB are differentially localized at the postsynaptic density opposite distinct motoneurons. Hence, innervating motoneurons may regulate the subunit composition of their receptor fields within a shared postsynaptic cell. The capacity of presynaptic inputs to shape the subunit composition of postsynaptic receptors could be an important mechanism for synapse-specific regulation of synaptic function and plasticity.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QL Zoology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Drosophila -- Genetics, Glutamic acid, Neuromuscular transmission, Neural transmission -- Regulation | ||||
Journal or Publication Title: | Journal of Neuroscience | ||||
Publisher: | Society for Neuroscience | ||||
ISSN: | 0270-6474 | ||||
Official Date: | 11 February 2004 | ||||
Dates: |
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Volume: | Vol.24 | ||||
Number: | No.6 | ||||
Page Range: | pp. 1406-1415 | ||||
DOI: | 10.1523/JNEUROSCI.1575-03.2004 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | National Institutes of Health (U.S.) (NIH), National Research Service Award Training Grant (NRSATG), W. M. Keck Foundation, McKnight Foundation (MF), Howard Hughes Medical Institute, Burroughs Wellcome Fund (BWF), Alfred P. Sloan Foundation | ||||
Grant number: | RO1 NS043171 (NIH), NS44754-01 (NRSATG) |
Data sourced from Thomson Reuters' Web of Knowledge
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