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Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A
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Tomprefa, N., McQuilken, M. P., Hill, R. A. and Whipps, J. M. (2009) Antimicrobial activity of Coniothyrium minitans and its macrolide antibiotic macrosphelide A. Journal of Applied Microbiology, Vol.106 (No.6). pp. 2048-2056. doi:10.1111/j.1365-2672.2009.04174.x ISSN 1364-5072.
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Official URL: http://dx.doi.org/10.1111/j.1365-2672.2009.04174.x
Abstract
Aims: Assessment of antimicrobial activity of the mycoparasite Coniothyrium minitans and its macrolide antibiotic macrosphelide A.
Methods and Results: Thirteen isolates of C minitans were tested for ability to inhibit a number of filamentous fungi, yeasts, oomycetes and bacteria in agar based tests. Activity was found against some ascomycetes, basidiomycetes, oomycetes and Gram-positive bacteria, but not against zygomycetes, yeasts or Gram-negative bacteria tested. Six C. minitans isolates (Conio, Contans, IVT1, CM/AP/3118, B279/1, Al/327/1) were found to produce macrosphelide A in liquid culture and no other antibiotics were detected. On agar, macrosphelide A inhibited growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a minimum inhibitory concentration of <= 500 mu g ml(-1). There was no inhibition observed against the yeasts and Gram-negative bacteria when macrosphelide A was tested at 700 mu g ml(-1).
Conclusions: The spectrum and level of activity of macrosphelide A produced by C. minitans against micro-organisms are extended markedly compared to previous reports.
Significance and Impact of the Study: Macrosphelide A was effective against Staph. aureus. Further study on the control of this bacterium is merited in view of the development of antibiotic resistance.
Item Type: | Journal Article | ||||
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Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology |
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Journal or Publication Title: | Journal of Applied Microbiology | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 1364-5072 | ||||
Official Date: | June 2009 | ||||
Dates: |
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Volume: | Vol.106 | ||||
Number: | No.6 | ||||
Number of Pages: | 9 | ||||
Page Range: | pp. 2048-2056 | ||||
DOI: | 10.1111/j.1365-2672.2009.04174.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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