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Development of non-donor-specific HLA antibodies after kidney transplantation : frequency and clinical implications
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Briggs, D., Zehnder, Daniel and Higgins, Rob (2009) Development of non-donor-specific HLA antibodies after kidney transplantation : frequency and clinical implications. Contributions to Nephrology, Vol.162 . pp. 107-116. doi:10.1159/000170844 ISSN 0302-5144.
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Official URL: http://dx.doi.org/10.1159/000170844
Abstract
Patients undergoing renal transplantation frequently have non-donor-specific HLA antibodies (NDSA). There could be NDSA (e.g. a negative crossmatch in a sensitized patient), or could be donor-specific HLA antibodies (DSA) (e.g., antibody-incompatible transplantation). NDSA levels slowly fall in the first month after transplantation, but in some patients their levels initially rise during a rejection episode with increased synthesis of DSA. This could be due to antibodies binding with shared epitopes on donor-specific and non-donor-specific HLA, or due to non-specific immune upregulation. Further investigation of the levels of NDSA in the context of the levels of DSA and other immunoglobulins will lead to new insights into the control of DSA responses. Copyright (C) 2009 S. Karger AG, Basel
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Series Name: | CONTRIBUTIONS TO NEPHROLOGY | ||||
Journal or Publication Title: | Contributions to Nephrology | ||||
Publisher: | Karger | ||||
ISSN: | 0302-5144 | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | Vol.162 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 107-116 | ||||
DOI: | 10.1159/000170844 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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