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Synthesis of 1,1-disubstituted tetrahydro-beta-carbolines from 2-methyleneaziridines
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Mumford, Peter M., Shiers, Jason J., Tarver, Gary J., Hayes, Jerome F. and Shipman, Michael (2008) Synthesis of 1,1-disubstituted tetrahydro-beta-carbolines from 2-methyleneaziridines. Tetrahedron Letters, Vol.49 (No.21). pp. 3489-3491. doi:10.1016/j.tetlet.2008.03.095 ISSN 00404039.
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2008.03.095
Abstract
Ring opening of indole functionalised methyleneaziridines (3a-c, 7) with alcohols in the presence of boron trifluoride etherate leads to the formation of 1,1-disubstituted tetrahydro-beta-carbolines in moderate to good yields (37-83%). (c) 2008 Elsevier Ltd. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Heterocyclic compounds, Ring-opening polymerization, Aziridines | ||||
Journal or Publication Title: | Tetrahedron Letters | ||||
Publisher: | Pergamon | ||||
ISSN: | 00404039 | ||||
Official Date: | 19 May 2008 | ||||
Dates: |
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Volume: | Vol.49 | ||||
Number: | No.21 | ||||
Number of Pages: | 3 | ||||
Page Range: | pp. 3489-3491 | ||||
DOI: | 10.1016/j.tetlet.2008.03.095 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Organon (Firm), GlaxoSmithKline | ||||
Grant number: | BBSSL-200512206 (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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