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Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs
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Williams, Jonathan P. and Scrivens, James H. (2008) Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs. Rapid Communications in Mass Spectrometry, Vol.22 (No.2). pp. 187-196. doi:10.1002/rcm.3346 ISSN 0951-4198.
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Official URL: http://dx.doi.org/10.1002/rcm.3346
Abstract
Desorption electrospray ionisation (DESI) and neutral desorption/extractive electrospray ionisation (EESI) have been coupled to a hybrid quadrupole travelling-wave (T-Wave)-based ion mobility time-of-flight mass spectrometer for the direct accurate mass analysis of active ingredients formulated into pharmaceutical samples. The collision cross-section measurements of polyethylene glycol (PEG) excipients detected in one formulation were estimated and compared with published data. These estimated collision cross-sections of the PEG species showed good agreement with published data. Copyright (c) 2007 John Wiley & Sons, Ltd.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Electrospray ionization mass spectrometry, Ion mobility spectroscopy, Drugs -- Analysis | ||||
Journal or Publication Title: | Rapid Communications in Mass Spectrometry | ||||
Publisher: | John Wiley & Sons Ltd. | ||||
ISSN: | 0951-4198 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Vol.22 | ||||
Number: | No.2 | ||||
Number of Pages: | 10 | ||||
Page Range: | pp. 187-196 | ||||
DOI: | 10.1002/rcm.3346 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Wellcome Trust (London, England) |
Data sourced from Thomson Reuters' Web of Knowledge
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