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Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta
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UNSPECIFIED (2005) Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. JOURNAL OF CELL SCIENCE, 118 (22). pp. 5279-5289. doi:10.1242/jcs.02647 ISSN 0021-9533.
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Official URL: http://dx.doi.org/10.1242/jcs.02647
Abstract
Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these Dvl-2-containing structures correspond to intracellular vesicles and may be involved in the Wnt signal transduction process. We report that cytoplasmic puncta are primarily formed in cells expressing Dvl-2 at high levels. Lower levels of expression can activate signalling without forming puncta. The structures do not localise with markers of the early or late endocytic pathway and time-lapse analysis demonstrates that Dvl-2 puncta move in a random fashion over short distances but do not originate from the plasma membrane. Based on our findings, we propose that Dvl-2 puncta are protein aggregates that are not required for signalling.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Journal or Publication Title: | JOURNAL OF CELL SCIENCE | ||||
Publisher: | COMPANY OF BIOLOGISTS LTD | ||||
ISSN: | 0021-9533 | ||||
Official Date: | 15 November 2005 | ||||
Dates: |
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Volume: | 118 | ||||
Number: | 22 | ||||
Number of Pages: | 11 | ||||
Page Range: | pp. 5279-5289 | ||||
DOI: | 10.1242/jcs.02647 | ||||
Publication Status: | Published |
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