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Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
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Bell, David J., Wootton, Daniel G., Mukaka, Mavuto, Montgomery, Jacqui, Kayange, Noel, Chimpeni, Phillips, Hughes, Dyfrig, Molyneux, Malcolm E., Ward, Steve A., Winstanley, Peter and Lalloo, David G. (2009) Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malaria Journal, Vol.8 (No.204). doi:10.1186/1475-2875-8-204 ISSN 1475-2875.
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Official URL: http://dx.doi.org/10.1186/1475-2875-8-204
Abstract
Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were considered possible alternatives to SP in Malawi. The aim of this study was to investigate the impact of poor adherence on the effectiveness of AL and CPD.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Malaria -- Treatment -- Malawi | ||||
Journal or Publication Title: | Malaria Journal | ||||
Publisher: | BioMed Central Ltd. | ||||
ISSN: | 1475-2875 | ||||
Official Date: | 29 August 2009 | ||||
Dates: |
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Volume: | Vol.8 | ||||
Number: | No.204 | ||||
DOI: | 10.1186/1475-2875-8-204 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 17 December 2015 | ||||
Date of first compliant Open Access: | 17 December 2015 | ||||
Funder: | Great Britain. Dept. for International Development | ||||
Grant number: | RES 8074 (DID) |
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