The Library
Optimised ‘click’ synthesis of glycopolymers with mono/di- and trisaccharides
Tools
Vinson, Nicola, Gou, Yanzi, Becer, C. Remzi, Haddleton, David M. and Gibson, Matthew I. (2011) Optimised ‘click’ synthesis of glycopolymers with mono/di- and trisaccharides. Polymer Chemistry, Vol.2 (No.1). pp. 107-113. doi:10.1039/c0py00260g ISSN 1759-9954.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1039/C0PY00260G
Abstract
In this paper we investigate the optimum procedure for the post-polymerisation modification of alkyne-bearing polymer scaffolds with glycosyl azides. We first elaborate the one-pot synthesis of glycosyl azides, in aqueous solution, without the need for protecting groups and in multigram scale. Using these azides, the ligand tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) was shown to give the fastest kinetics for the ‘click’ reaction at ambient temperature, and was used to prepare homogenous oligosaccharide-modified glycopolymers. The terminal sugars of these oligosaccharides were used to introduce α-linked glucose which is typically synthetically challenging.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Polymerization, Organic compounds -- Synthesis, Ligand binding (Biochemistry), Polymers | ||||
Journal or Publication Title: | Polymer Chemistry | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1759-9954 | ||||
Official Date: | January 2011 | ||||
Dates: |
|
||||
Volume: | Vol.2 | ||||
Number: | No.1 | ||||
Page Range: | pp. 107-113 | ||||
DOI: | 10.1039/c0py00260g | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), China Scholarship Council (CSC), European Union (EU) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |