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Optimal oral drug dosing via application of the contraction mapping theorem
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Evans, Neil D. (2011) Optimal oral drug dosing via application of the contraction mapping theorem. Biomedical Signal Processing and Control, Vol.6 (No.1). pp. 57-63. doi:10.1016/j.bspc.2010.06.006 ISSN 1746-8094.
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WRAP_Evans_9871863-es-081211-paper.pdf - Accepted Version - Requires a PDF viewer. Download (311Kb) |
Official URL: http://dx.doi.org/10.1016/j.bspc.2010.06.006
Abstract
The problem of determining an oral dose, or schedule of oral doses, that gives rise to an arbitrary area-under-curve or to points on the time-series for a variable of interest in a drug kinetics model is considered. These two measures are considered as surrogates for the particular drug response to the dose. The approach taken is to formulate the problem as a fixed point one to which a version of the contraction mapping theorem can be applied. The results, illustrated for a model for the anti-cancer agent topotecan, demonstrate the applicability of the approach.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RM Therapeutics. Pharmacology T Technology > TA Engineering (General). Civil engineering (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Library of Congress Subject Headings (LCSH): | Pharmacokinetics -- Mathematical models | ||||
Journal or Publication Title: | Biomedical Signal Processing and Control | ||||
Publisher: | Elsevier BV | ||||
ISSN: | 1746-8094 | ||||
Official Date: | January 2011 | ||||
Dates: |
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Volume: | Vol.6 | ||||
Number: | No.1 | ||||
Page Range: | pp. 57-63 | ||||
DOI: | 10.1016/j.bspc.2010.06.006 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Description: | Biomedical signal processing (Extended selected papers from the 7th IFAC Symposium on Modelling and Control in Biomedical Systems(MCBMS'09)) |
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Date of first compliant deposit: | 17 December 2015 | ||||
Date of first compliant Open Access: | 17 December 2015 | ||||
Version or Related Resource: | This item was originally submitted to the 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Aalborg, Denmark, Aug 12 - 14, 2009. |
Data sourced from Thomson Reuters' Web of Knowledge
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