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Personalized medicine : the impact on chemistry
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Watkins, John, Marsh, Andrew, Taylor, Paul C. and Singer, Donald R. J. (2010) Personalized medicine : the impact on chemistry. Therapeutic Delivery, Vol.1 (No.5). pp. 651-665. doi:10.4155/tde.10.64 ISSN 2041-5990.
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Official URL: http://dx.doi.org/10.4155/tde.10.64
Abstract
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift, that of network pharmacology. We examine the intersection of personalized medicine and network pharmacology to identify strategies for the development of personalized therapies that are fully informed by network pharmacology concepts. This provides a framework for discussion of the impact personalized medicine will have on chemistry in terms of drug discovery, formulation and delivery, the adaptations and changes in ideology required and the contribution chemistry is already making. New ways of conceptualizing chemistry’s relationship with medicine will lead to new approaches to drug discovery and hold promise of delivering safer and more effective therapies.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
Library of Congress Subject Headings (LCSH): | Pharmacogenomics, Drugs -- Effectiveness, Drug development | |||||||||
Journal or Publication Title: | Therapeutic Delivery | |||||||||
Publisher: | Future Science Ltd. | |||||||||
ISSN: | 2041-5990 | |||||||||
Official Date: | November 2010 | |||||||||
Dates: |
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Volume: | Vol.1 | |||||||||
Number: | No.5 | |||||||||
Page Range: | pp. 651-665 | |||||||||
DOI: | 10.4155/tde.10.64 | |||||||||
Status: | Peer Reviewed | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Tangent Reprofiling Ltd | |||||||||
RIOXX Funder/Project Grant: |
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