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Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells
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Ciobanu, Mihai, Huang, Kuo-Ting, Daguer, Jean-Pierre, Barluenga, Sofia, Chaloin, Olivier, Schaeffer, Evelyne, Mueller, Christopher G., Mitchell, Daniel A. and Winssinger, Nicolas (2011) Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells. Chemical Communications, Vol.47 (No.33). pp. 9321-9323. doi:10.1039/c1cc13213j ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/c1cc13213j
Abstract
We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Oligomers, Drug development, Pharmaceutical chemistry, Oligosaccharides, Peptides, Nucleic acids, DNA-ligand interactions | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol.47 | ||||
Number: | No.33 | ||||
Page Range: | pp. 9321-9323 | ||||
DOI: | 10.1039/c1cc13213j | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | European Research Council (ERC), Institut Universitaire de France (IUF) | ||||
Grant number: | ERC 201749 (ERC) |
Data sourced from Thomson Reuters' Web of Knowledge
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