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Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
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Yamin, Rina, Zhao, Cheng, O'Connor, Peter B., McKee, Ann C. and Abraham, Carmela R. (2009) Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Molecular Neurodegeneration, Vol.4 (No.1). Article: 33. doi:10.1186/1750-1326-4-33 ISSN 1750-1326.
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Official URL: http://dx.doi.org/10.1186/1750-1326-4-33
Abstract
The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and aggregates, and in senile plaques, fibrils. Recent findings suggest that soluble amyloid-beta oligomers may represent the primary pathological species in Alzheimer's disease and the most toxic form that impairs synaptic and thus neuronal function. We previously reported the isolation of a novel amyloid-beta-degrading enzyme, acyl peptide hydrolase, a serine protease that degrades amyloid-beta, and is different in structure and activity from other amyloid-beta-degrading enzymes.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Amyloid beta-protein, Hydrolases, Alzheimer's disease -- Etiology, Neurotoxicology, Peptides, Mass spectrometry | ||||
Journal or Publication Title: | Molecular Neurodegeneration | ||||
Publisher: | BioMed Central Ltd. | ||||
ISSN: | 1750-1326 | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | Vol.4 | ||||
Number: | No.1 | ||||
Number of Pages: | 10 | ||||
Page Range: | Article: 33 | ||||
DOI: | 10.1186/1750-1326-4-33 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Alzheimer's Association, National Institutes of Health (U.S.) (NIH), National Institute on Aging (NIA), Boston University. Alzheimer's Disease Centre (ADC), United States. Department of Veterans Affairs | ||||
Grant number: | IIRG-02-3783 (AA), P01-AG00001 (NIA), NIA P30 AG13846 (ADC) |
Data sourced from Thomson Reuters' Web of Knowledge
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