The Library
Exact firing-rate response of the integrate-and-fire neuron receiving finite amplitude excitatory and inhibitory post-synaptic potentials
Tools
Richardson, Magnus J. E. and Swarbrick, Rupert (2011) Exact firing-rate response of the integrate-and-fire neuron receiving finite amplitude excitatory and inhibitory post-synaptic potentials. BMC Neuroscience, Vol.12 (Suppl.1). O18. doi:10.1186/1471-2202-12-S1-O18
|
PDF
WRAP_Richardson_1471-2202-12-S1-O18.pdf - Published Version - Requires a PDF viewer. Download (185Kb) |
Official URL: http://dx.doi.org/10.1186/1471-2202-12-S1-O18
Abstract
Neurons in active networks are subject to a fluctuating
synaptic drive comprising excitatory and inhibitory postsynaptic
potentials arriving at high rates relative to the
integration time of the cell. The standard approach for
treating stochastic synaptic currents and conductances
has been to approximate them by a Gaussian whitenoise
or coloured-noise process in which the amplitudes
of the underlying post-synaptic potentials are considered
small. Importantly, this diffusion approximation has
allowed for various firing-rate properties of populations
of fluctuation-driven neurons to be calculated using
Johanessma’s [1] and Ricciardi’s [2] Fokker-Planck framework.
This framework in turn has proven to be a
powerful theoretical tool for deriving the emergent
states of coupled neuronal networks as a function of the
properties of constituent neurons. The Gaussian/diffusion
model of fluctuating synaptic conductance is in
widespread use theoretically, computationally and
experimentally and, in many cases, is an excellent
approximation to the synaptic drive experienced by neurons
in active networks in vitro or in vivo.
Item Type: | Journal Item | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre | ||||
Library of Congress Subject Headings (LCSH): | Neurons -- Mathematical models | ||||
Journal or Publication Title: | BMC Neuroscience | ||||
Publisher: | Bio Med Central | ||||
ISSN: | 1471-2202 | ||||
Official Date: | 2011 | ||||
Dates: |
|
||||
Volume: | Vol.12 | ||||
Number: | Suppl.1 | ||||
Page Range: | O18 | ||||
DOI: | 10.1186/1471-2202-12-S1-O18 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 1 August 2016 | ||||
Date of first compliant Open Access: | 1 August 2016 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year