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Sensitivity, robustness, and identifiability in stochastic chemical kinetics models
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Komorowski, Michal, Costa, Maria J. (Maria João), Rand, D. A. (David A.) and Stumpf, M. P. H. (Michael P. H.) (2011) Sensitivity, robustness, and identifiability in stochastic chemical kinetics models. Proceedings of the National Academy of Sciences, Volume 108 (Number 21). pp. 8645-8650. doi:10.1073/pnas.1015814108 ISSN 0027-8424.
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Official URL: http://dx.doi.org/10.1073/pnas.1015814108
Abstract
We present a novel and simple method to numerically calculate Fisher information matrices for stochastic chemical kinetics models. The linear noise approximation is used to derive model equations and a likelihood function that leads to an efficient computational algorithm. Our approach reduces the problem of calculating the Fisher information matrix to solving a set of ordinary differential equations. This is the first method to compute Fisher information for stochastic chemical kinetics models without the need for Monte Carlo simulations. This methodology is then used to study sensitivity, robustness, and parameter identifiability in stochastic chemical kinetics models. We show that significant differences exist between stochastic and deterministic models as well as between stochastic models with time-series and time-point measurements. We demonstrate that these discrepancies arise from the variability in molecule numbers, correlations between species, and temporal correlations and show how this approach can be used in the analysis and design of experiments probing stochastic processes at the cellular level. The algorithm has been implemented as a Matlab package and is available from the authors upon request.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QA Mathematics Q Science > QD Chemistry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Stochastic processes, Chemical kinetics -- Mathematical models, Systems biology | ||||
Journal or Publication Title: | Proceedings of the National Academy of Sciences | ||||
Publisher: | National Academy of Sciences | ||||
ISSN: | 0027-8424 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Volume 108 | ||||
Number: | Number 21 | ||||
Page Range: | pp. 8645-8650 | ||||
DOI: | 10.1073/pnas.1015814108 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), European Union (EU), Royal Society (Great Britain) | ||||
Grant number: | BB/G020434/1 (BBSRC), GR/S29256/01 (EPSRC), BB/F005261/1 (BBSRC and EPSRC), 005137 (EU) |
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